Stem Cells http://www.stemcellsportal.com/
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

First published online November 2, 2006
OPEN ACCESS ARTICLE
This Article
Free via Open Access: OA
Right arrow Full Text (PDF)
Right arrowOA All Versions of this Article:
2006-0364v1
25/2/263    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Geraerts, M.
Right arrow Articles by Debyser, Z.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Geraerts, M.
Right arrow Articles by Debyser, Z.
Submitted on June 13, 2006
Accepted on October 30, 2006

Tissue-Specific Stem Cells

Therapeutic strategies for Parkinson's disease based on the modulation of adult neurogenesis

Martine Geraerts 1, Olga Krylychkina 1, Veerle Baekelandt 2, Zeger Debyser 1*

1 Laboratory for Molecular Virology and Gene Therapy, K.U.Leuven and IRC KULAK, Flanders, Belgium
2 Laboratory for Neurobiology and Gene Therapy, K.U.Leuven, Flanders, Belgium

* To whom correspondence should be addressed. E-mail: Zeger.Debyser{at}med.kuleuven.be.


  Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder, affecting millions of people world-wide. To date, treatment strategies are mainly symptomatic and aimed at increasing dopamine levels in the degenerating nigrostriatal system. Hope rests upon the development of effective neurorestorative or neuroregenerative therapies based on gene and stem cell therapy or a combination of both. The results of experimental therapies based on transplanting exogenous dopamine-rich fetal cells or growth factor (GDNF) overexpression into the brain of Parkinson's disease patients encourage future cell- and gene-based strategies. The endogenous neural stem cells of the adult brain provide an alternative and attractive cell source for neuroregeneration. Prior to designing endogenous stem cell therapies, one has to investigate the possible impact of PD on adult neuronal stem cell pools and their neurogenic potential. We review the experimental data obtained in animal models or based on analysis of patients' brain prior to describing different treatment strategies. Strategies aiming to enhance neuronal stem cell proliferation and/or differentiation in the striatum or the substantia nigra will have to be compared in animal models and selected prior to clinical studies.

Key Words. neurogenesis, Parkinson's disease, adult neural stem cell, cell therapy




This article has been cited by other articles:


Home page
 Stem CellsHome page
A. Hermann and A. Storch
Endogenous Regeneration in Parkinson's Disease: Do We Need Orthotopic Dopaminergic Neurogenesis?
Stem Cells, November 1, 2008; 26(11): 2749 - 2752.
[Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
S. Vale
Current Management of the Cognitive Dysfunction in Parkinson's Disease: How Far Have We Come?
Experimental Biology and Medicine, August 1, 2008; 233(8): 941 - 951.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS

Copyright © 2006 by AlphaMed Press.