Stem Cells http://www.peprotech.com/
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

First published online November 9, 2006
This Article
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
2006-0562v1
25/3/731    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Joannides, A. J.
Right arrow Articles by Chandran, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Joannides, A. J.
Right arrow Articles by Chandran, S.
Submitted on September 4, 2006
Accepted on November 3, 2006

Embryonic Stem Cells

A scaleable and defined system for generating neural stem cells from human embryonic stem cells

Alexis J. Joannides 1, Christelle Fiore-Hériché 1, Alysia A. Battersby 2, Pandula Athauda-arachchi 1, Isabelle A. Bouhon 1, Lydia Williams 2, Kristine Westmore 1, Paul J. Kemp 2, Alastair Compston 1, Nicholas D. Allen 2, Siddharthan Chandran 1*

1 Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, Cambridge, United Kingdom
2 School of Biosciences, Cardiff University, Cardiff, United Kingdom

* To whom correspondence should be addressed. E-mail: sc222{at}cam.ac.uk.


  Abstract

The ability to differentiate human embryonic stem cells (hESCs) to defined lineages in a totally controlled manner is fundamental to developing cell-based therapies and studying human developmental mechanisms. We report a novel, scaleable and widely-applicable system for deriving and propagating neural stem cells from hESCs without the use of animal products, proprietary formulations or genetic manipulation. This system provides a definitive platform for studying human neural development and has potential therapeutic implications.

Key Words. human embryonic stem cells, neural stem cells, defined conditions, FGF




This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
G. W. Yeo, N. Coufal, S. Aigner, B. Winner, J. A. Scolnick, M. C.N. Marchetto, A. R. Muotri, C. Carson, and F. H. Gage
Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells
Hum. Mol. Genet., April 15, 2008; 17(R1): R67 - R75.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Jones, N. Horwood, A. Cope, and F. Dazzi
The Antiproliferative Effect of Mesenchymal Stem Cells Is a Fundamental Property Shared by All Stromal Cells
J. Immunol., September 1, 2007; 179(5): 2824 - 2831.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. J. Joannides, D. J. Webber, O. Raineteau, C. Kelly, K.-A. Irvine, C. Watts, A. E. Rosser, P. J. Kemp, W. F. Blakemore, A. Compston, et al.
Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells
Brain, May 1, 2007; 130(5): 1263 - 1275.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS
http://www.peprotech.com/
Copyright © 2006 by AlphaMed Press.