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Tissue-Specific Stem Cells |
1 Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York
2 Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky
* To whom correspondence should be addressed. E-mail: piero_anversa{at}nymc.edu.
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Abstract |
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This review discusses the controversy that has permeated the field of myocardial regeneration in the last three decades. The notion of the heart as a terminally differentiated postmitotic organ has been so strong that observations promoting the opposite paradigm have been questioned technically and conceptually. The possibility of misinterpretation of results collected with cellular, molecular, and morphological methodologies has been the prevailing position in the scientific community. Myocardial regeneration mediated by activation of endogenous progenitor cells or by engraftment and differentiation of primitive cells from the bone marrow has been rejected strongly in an attempt to defend an unrealistic view of the heart. This article provides evidence in support of the notion that the heart is an organ regulated by a stem cell compartment responsible for cardiac homeostasis and repair.
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