Stem Cells http://www.peprotech.com/
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

First published online March 22, 2007
OPEN ACCESS ARTICLE
This Article
Free via Open Access: OA
Right arrow Full Text (PDF)
Right arrowOA All Versions of this Article:
2006-0644v1
25/6/1339    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Holmes, C.
Right arrow Articles by Stanford, W. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holmes, C.
Right arrow Articles by Stanford, W. L.
Submitted on October 10, 2006
Accepted on March 2, 2007

Tissue-Specific Stem Cells

Stem Cell Antigen-1: Expression, Function, and Enigma

Christina Holmes 1 and William L. Stanford 2*

1 Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada
2 Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada; Department of Chemical Engineering and Applied Chemistry, and Institute of Medical Science, University of Toronto, Toronto, Canada

* To whom correspondence should be addressed. E-mail: william.stanford{at}utoronto.ca.


  Abstract

Cloned 20 years ago, Stem Cell Antigen-1 (Sca-1) is used extensively to enrich for murine hematopoietic stem cells (HSC). The realization that many different stem cell types share conserved biochemical pathways has led to a flood of recent research using Sca-1 as a candidate marker in the search for tissue-resident and cancer stem cells. While surprisingly little is still known about its biochemical function, the generation and analysis of knockout mice has begun to shed light on the functions of Sca-1 in stem and progenitor cells, demonstrating that it is more than a convenient marker for stem cell biologists. This review summarizes the plethora of recent findings utilizing Sca-1 as a parenchymal stem cell marker and detailing its functional role in stem and progenitor cells, as well as attempt to explain the lingering mysteries surrounding its biochemical function and human orthologue.

Key Words. Sca 1, Ly 6A, Stem Cell, Self-Renewal, GPI-anchored protein, lipid rafts




This article has been cited by other articles:


Home page
 Circ. Res.Home page
H. Reinecke, E. Minami, W.-Z. Zhu, and M. A. Laflamme
Cardiogenic Differentiation and Transdifferentiation of Progenitor Cells
Circ. Res., November 7, 2008; 103(10): 1058 - 1071.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
M. Hidestrand, S. Richards-Malcolm, C. M. Gurley, G. Nolen, B. Grimes, A. Waterstrat, G. V. Zant, and C. A. Peterson
Sca-1-Expressing Nonmyogenic Cells Contribute to Fibrosis in Aged Skeletal Muscle
J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2008; 63(6): 566 - 579.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
C. Naujokat and T. Saric
Concise Review: Role and Function of the Ubiquitin-Proteasome System in Mammalian Stem and Progenitor Cells
Stem Cells, October 1, 2007; 25(10): 2408 - 2418.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS
http://www.peprotech.com/
Copyright © 2007 by AlphaMed Press.