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First published online July 19, 2007
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2007-0255v1
25/10/2408    most recent
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Submitted on April 5, 2007
Accepted on July 10, 2007

TISSUE-SPECIFIC STEM CELLS

Concise Review: Role and Function of the Ubiquitin-Proteasome System in Mammalian Stem and Progenitor Cells

Cord Naujokat 1* and Tomo Saric 2

1 Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D-69120 Heidelberg, Germany
2 Center for Physiology, Medical Faculty of the University of Cologne, Robert Koch Straße 39, 50931 Cologne, Germany

* To whom correspondence should be addressed. E-mail: cord.naujokat{at}med.uni-heidelberg.de.


  Abstract

Highly ordered degradation of cell proteins by the ubiquitin-proteasome system, a sophisticated cellular proteolytic machinery, has been identified as a key regulatory mechanism in many eukaryotic cells. Accumulating evidence reveals that the ubiquitin-proteasome system is involved in the regulation of fundamental processes in mammalian stem and progenitor cells of embryonic, neural, hematopoietic and mesenchymal origin. Such processes, including development, survival, differentiation, lineage commitment, migration and homing, are directly controlled by the ubiquitin-proteasome system, either via proteolytic degradation of key regulatory proteins of signaling and gene expression pathways or via non-proteolytic mechanisms involving proteasomes itself or posttranslational modifications of target proteins by ubiquitin or other ubiquitin-like modifiers. Future characterization of the precise roles and functions of the ubiquitin-proteasome system in mammalian stem and early progenitor cells will improve our understanding of stem cell biology and may provide an experimental basis for the development of novel therapeutic strategies in regenerative medicine.

Key Words. Embryonic stem cells, Neural stem cells, Hematopoietic stem cells, Mesenchymal stem cells, Ubiquitin, Proteasome




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