Submitted on April 24, 2007
Accepted on July 20, 2007
TISSUE-SPECIFIC STEM CELLS
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CD45-positive Blood Cells Give Rise to Uterine Epithelial Cells in Mice
András Bratincsák 1,
Michael J. Brownstein ,
Riccardo Cassiani-Ingoni 2,
Sandra Pastorino ,
Ildikó Szalayova 3,
Zsuzsanna E. Tóth 3,
Sharon Key 3,
Krisztián Németh 3,
James Pickel 1,
Éva Mezey 3*
1 NIMH
2 NINDS, NCI
3 NIDCR, NIH, Bethesda, MD, (MJB) The J. Craig Venter Institute, Gaithersburg, MD, & Department of Dermato-Venereology, Semmelweis University, Budapest, Hungary
* To whom correspondence should be addressed. E-mail: ezeye{at}mail.nih.gov.
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Abstract |
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The uterine endometrium is composed of epithelial and stromal cells, which undergo extensive degeneration and regeneration in every estrous cycle, and dramatic changes occur during pregnancy. The high turnover of cells requires a correspondingly high level of cell division by progenitor cells in the uterus but the character and source of these cells remain obscure. In the present study, using a novel transgenic mouse, we show that CD45 positive hematopoetic progeniotor cells colonize the uterine epithelium, and that in pregnancy more than 80% of the epithelium can derive from these cells. Since we also found GFP positive uterine endothelial cells in long term GFP bone marrow transplanted mice we conclude that circulating CD45+ cells play an important role in regenerating the uterine epithelium.
Key Words.
Adult stem cell, hematopoetic stem cell, endometrium, regeneration
