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First published online December 13, 2007
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2007-0484v1
26/3/638    most recent
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Submitted on June 19, 2007
Accepted on December 4, 2007

TISSUE-SPECIFIC STEM CELLS

Human Dental Pulp Stem Cells Improve Left Ventricular Function, Induce Angiogenesis and Reduce Infarct Size in Rats With Acute Myocardial Infarction

Carolina Gandia 1, Ana Armiñan 1, Jose Manuel García-Verdugo 2, Elisa Lledó 1, Amparo Ruiz 3, Mª Dolores Miñana 4, Jorge Sanchez-Torrijos 4, Rafael Payá 4, Vicente Mirabet 5, Francisco Carbonell-Uberos 5, Mauro LLop 1, Jose Anastasio Montero 6, Pilar Sepúlveda 7*

1 Unidad de Cardiorregeneración, Centro de Investigación Príncipe Felipe, Valencia, Spain
2 Unidad de Cardiorregeneración, Centro de Investigación Príncipe Felipe, Valencia, Spain; Universidad de Valencia, Valencia, Spain
3 Universidad de Valencia, Valencia, Spain
4 Fundación Hospital General Universitario, Valencia, Spain
5 Centro de Transfusion de la Comunidad Valenciana, Valencia, Spain
6 Unidad de Cardiorregeneración, Centro de Investigación Príncipe Felipe, Valencia, Spain; Hospital Universitario La Fe, Valencia, Spain
7 Unidad de Cardiorregeneración, Centro de Investigación Príncipe Felipe, Valencia, Spain; Fundación Hospital General Universitario, Valencia, Spain

* To whom correspondence should be addressed. E-mail: pilar.sepulveda{at}uv.es.


  Abstract

Human dental pulp contains precursor cells termed dental pulp stem cells (DPSC) that show self-renewal and multi-lineage differentiation and also secrete multiple pro-angiogenic and anti-apoptotic factors. To examine if these cells could have therapeutic potential in the repair of myocardial infarction (MI), DPSC were infected with a retrovirus encoding the GFP protein and expanded ex vivo. Seven days after induction of myocardial infarction by coronary artery ligation, 1.5x106 GFP-DPSC were injected intramyocardically in nude rats. At 4 weeks, cell treated animals showed an improvement in cardiac function, observed by percentage changes in anterior wall thickening (AWT) left ventricular fractional area change (FAC), in parallel with a reduction in infarct size. No histologic evidence was seen of GFP+ endothelial cells, smooth or cardiac muscle cells within the infarct. However, angiogenesis was increased relative to control treated animals. Taken together these data suggest that DPSC could provide a novel alternative cell population for cardiac repair, at least in the setting of acute MI.

______________________________________________________________________________

C. Gandia and A. Arminan contributed equally to this work.

 Key Words. Stem cell therapy, ventricular remodeling, left ventricular function, dental pulp stem cells




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[Abstract] [Full Text] [PDF]


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