Stem Cells
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online December 21, 2006
Stem Cells Vol. 25 No. 4 April 2007, pp. 844 -851
doi:10.1634/stemcells.2006-0346; www.StemCells.com
© 2007 AlphaMed Press

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2006-0346v1
25/4/844    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bullock, T. E.
Right arrow Articles by Gordon, M. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bullock, T. E.
Right arrow Articles by Gordon, M. Y.

TISSUE-SPECIFIC STEM CELLS

Potential of CD34 in the Regulation of Symmetrical and Asymmetrical Divisions by Hematopoietic Progenitor Cells

Tabitha E. Bullock, Baiping Wen, Stephen B. Marley, Myrtle Y. Gordon

Department of Haematology, Imperial College Faculty of Medicine, Hammersmith Campus, London, United Kingdom

Key Words. Adhesion molecules • Stem cell asymmetry • Self-renewal • Hematopoietic stem cells • CD34+

Correspondence: Myrtle Y. Gordon, Ph.D., D.Sc., Department of Haematology, Imperial College Faculty of Medicine, Hammersmith Campus, Du Cane Road, London W12 ONN, U.K. Telephone: +44-20-8383-3430; e-mail: myrtle.gordon{at}imperial.ac.uk

Received June 6, 2006; accepted for publication December 6, 2006.
First published online in STEM CELLS EXPRESS   December 21, 2006.



The control of symmetric and asymmetric division in the hematopoietic stem/progenitor cell population is critically important for the regulation of blood cell production. Asymmetric divisions depend on cell polarization, which may be conferred by location and/or interaction with neighboring cells. In this study, we sought evidence for polarization in CD34+ cells, which interact by binding to one another. In these cells, surface molecules became redistributed by mechanisms that included transport by lipid rafts, and the interacting cells were able to communicate via gap junctions. These changes were accompanied by modulation of cell cycle regulating proteins (p16Ink4a, p27kip1, cyclins D, and the retinoblastoma pathway proteins) and a reduction in progenitor cell proliferation in vitro. These results are consistent with an increase in asymmetric cell division kinetics. Accordingly, we found that interaction between CD34+ cells influenced the plane of cell division in a way that suggests unequal sharing of Notch-1 between daughter cell progeny. We conclude that interaction between CD34+ cells may coordinate cell function and participate in the control of hematopoietic stem/progenitor cell division kinetics.

Disclosure of potential conflicts of interest is found at the end of this article.




This article has been cited by other articles:


Home page
 Stem CellsHome page
S. Salati, R. Zini, E. Bianchi, A. Testa, F. Mavilio, R. Manfredini, and S. Ferrari
Role of CD34 Antigen in Myeloid Differentiation of Human Hematopoietic Progenitor Cells
Stem Cells, April 1, 2008; 26(4): 950 - 959.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS

Copyright © 2007 by AlphaMed Press.