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THE STEM CELL NICHE

Concise Review: Dendritic Cell Development in the Context of the Spleen Microenvironment

School of Biochemistry and Molecular Biology, The Australian National University, Canberra, Australian Capital Territory, Australia

Key Words. Dendritic cell development • Spleen • Hematopoiesis • Niche • Microenvironment

Correspondence: Helen C. O'Neill, B.Sc., Ph.D., School of Biochemistry & Molecular Biology, Bldg. #41 Linnaeus Way, Canberra, Australian Capital Territory, Australia 0200. Telephone: +61 2 61254720; Fax: +61 2 6125 0313; e-mail: Helen.ONeill{at}anu.edu.au

Received April 2, 2007; accepted for publication May 17, 2007.
First published online in STEM CELLS EXPRESS   May 24, 2007.



The dendritic cell (DC) population in spleen comprises a mixture of cells including endogenous DC progenitors, DC precursors migrating in from blood and bone marrow, and DC in different states of differentiation and activation. A role for different microenvironments in supporting the dynamic development of murine DC of different types or lineages is considered here. Recent evidence for production of DC dependent on splenic stromal cells is reviewed in the light of evidence that cell production is dependent on cells comprising an endothelial niche in spleen. The possibility that self-renewing progenitors in spleen give rise to DC with tolerogenic or regulatory rather than immunostimulatory function is considered.

Disclosure of potential conflicts of interest is found at the end of this article.

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