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EMBRYONIC STEM CELLS

Zfp206 Is a Transcription Factor That Controls Pluripotency of Embryonic Stem Cells

^aDepartment of Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore;
^bDepartment of General Surgery, Jin Cheng Hospital of Lan Zhou, Lan Zhou, People's Republic of China;
^cDepartment of Biological Sciences, National University of Singapore, Singapore

Key Words. Transcription factor • Stem cells • Differentiation • Gene expression • Pluripotency

Correspondence: Lawrence W. Stanton, Ph.D., Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672. Telephone: 65-6478-8000; Fax: 65-6478-9051; e-mail: stantonl{at}gis.a-star.edu.sg

Received January 31, 2007; accepted for publication May 11, 2007.
First published online in STEM CELLS EXPRESS   July 12, 2007.



Zfp206 (ZNF206 in human) encodes a zinc finger- and SCAN domain-containing protein that is highly expressed in pluripotent ESC. Upon differentiation of human and mouse ESC, Zfp206 expression is quickly repressed. Zfp206 was found to be expressed throughout embryogenesis but absent in adult tissues except testis. We have identified a role for Zfp206 in controlling ESC differentiation. ESC engineered to overexpress Zfp206 were found to be resistant to differentiation induced by retinoic acid. In addition, ESC with knocked-down expression of Zfp206 were more sensitive to differentiation by retinoic acid treatment. We found that Zfp206 was able to enhance expression from its own promoter and also activate transcription of the Oct4 and Nanog promoters. Our results show that Zfp206 is an embryonic transcription factor that plays a role in regulating pluripotency of embryonic stem cells.

Disclosure of potential conflicts of interest is found at the end of this article.

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