Stem Cells http://www.stemcellsportal.com/
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online May 31, 2007
Stem Cells Vol. 25 No. 9 September 2007, pp. 2277 -2282
doi:10.1634/stemcells.2006-0705; www.StemCells.com
© 2007 AlphaMed Press

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
2006-0705v1
25/9/2277    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shechter, R.
Right arrow Articles by Schwartz, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shechter, R.
Right arrow Articles by Schwartz, M.

TISSUE-SPECIFIC STEM CELLS

New GABAergic Interneurons Supported by Myelin-Specific T Cells Are Formed in Intact Adult Spinal Cord

Ravid Shechter, Yaniv Ziv, Michal Schwartz

Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel

Key Words. Neuroimmune • Neural stem cell • Autoimmunity • Stromal-derived factor-1 • Neural differentiation

Correspondence: Michal Schwartz, Ph.D., Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel. Telephone: 972-8-934-2467; Fax: 972-8-934-6018; e-mail: michal.schwartz{at}weizmann.ac.il

Received November 6, 2006; accepted for publication May 16, 2007.
First published online in STEM CELLS EXPRESS   May 31, 2007.



Neural stem/progenitor cells are known to exist in the intact spinal cord, but the presence of newly formed neurons during adulthood has not been documented there to date. Here, we report the appearance of newly formed neurons under normal physiological conditions. These neurons are immature, express a GABAergic phenotype, and are primarily located in the dorsal part of the spinal cord. This localization appeared to be mediated by stromal-derived factor-1/CXC-chemokine receptor-4 signaling in the dorsal region. The extent of spinal cord neurogenesis was found to be greatly influenced by immune system integrity and in particular by myelin-specific T cells. These observations provide evidence for in vivo spinal cord neurogenesis under nonpathological conditions and introduce novel mechanisms regulating adult spinal cord plasticity.

Disclosure of potential conflicts of interest is found at the end of this article.




This article has been cited by other articles:


Home page
 JCBHome page
R. Shechter, A. Ronen, A. Rolls, A. London, S. Bakalash, M. J. Young, and M. Schwartz
Toll-like receptor 4 restricts retinal progenitor cell proliferation
J. Cell Biol., November 3, 2008; 183(3): 393 - 400.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
F.-J. Obermair, A. Schroter, and M. Thallmair
Endogenous Neural Progenitor Cells as Therapeutic Target After Spinal Cord Injury
Physiology, October 1, 2008; 23(5): 296 - 304.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS
http://www.stemcellsportal.com/
Copyright © 2007 by AlphaMed Press.