Stem Cells http://www.stemcellsportal.com/
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online October 25, 2007
Stem Cells Vol. 26 No. 1 January 2008, pp. 89 -98
doi:10.1634/stemcells.2007-0151; www.StemCells.com
© 2008 AlphaMed Press

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2007-0151v1
26/1/89    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Koch, C. A.
Right arrow Articles by Platt, J. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Koch, C. A.
Right arrow Articles by Platt, J. L.

EMBRYONIC STEM CELLS

Immunosuppression by Embryonic Stem Cells

Cody A. Kocha,b, Pedro Geraldesa,b, Jeffrey L. Platta,b,c,d

aTransplantation Biology Program and
Departments of bImmunology,
cSurgery, and
dPediatrics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA

Key Words. Stem cells • T cells • Dendritic cells

Correspondence: Jeffrey L. Platt, M.D., Transplantation Biology, 2-66 Medical Sciences Building, Mayo Clinic, 200 1st Street SW, Rochester, Minnesota 55905, USA. Telephone: 507-538-0313; Fax: 507-284-4957; e-mail: platt.jeffrey{at}mayo.edu

Received February 28, 2007; accepted for publication October 19, 2007.
First published online in STEM CELLS EXPRESS   October 25, 2007.



Embryonic stem cells or their progeny inevitably differ genetically from those who might receive the cells as transplants. We tested the barriers to engraftment of embryonic stem cells and the mechanisms that determine those barriers. Using formation of teratomas as a measure of engraftment, we found that semiallogeneic and fully allogeneic embryonic stem cells engraft successfully in mice, provided a sufficient number of cells are delivered. Successfully engrafted cells did not generate immunological memory; unsuccessfully engrafted cells did. Embryonic stem cells reversibly, and in a dose-dependent manner, inhibited T-cell proliferation to various stimuli and the maturation of antigen-presenting cells induced by lipopolysaccharide. Inhibition of both was owed at least in part to production of transforming growth factor-β by the embryonic stem cells. Thus, murine embryonic stem cells exert "immunosuppression" locally, enabling engraftment across allogeneic barriers.

Disclosure of potential conflicts of interest is found at the end of this article.




This article has been cited by other articles:


Home page
 Stem CellsHome page
S. Yamada, T. J. Nelson, R. J. Crespo-Diaz, C. Perez-Terzic, X.-K. Liu, T. Miki, S. Seino, A. Behfar, and A. Terzic
Embryonic Stem Cell Therapy of Heart Failure in Genetic Cardiomyopathy
Stem Cells, October 1, 2008; 26(10): 2644 - 2653.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R.-J. Swijnenburg, S. Schrepfer, J. A. Govaert, F. Cao, K. Ransohoff, A. Y. Sheikh, M. Haddad, A. J. Connolly, M. M. Davis, R. C. Robbins, et al.
Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts
PNAS, September 2, 2008; 105(35): 12991 - 12996.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS

Copyright © 2008 by AlphaMed Press.