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Human BM MSC-mediated reconstruction of orofacial region in immunocompromised mice. Transplantation of BM MSCs using HA as a carrier vehicle significantly altered mouse facial appearance. Red dashed line represents original forehead (upper left). MSC nontransplanted control mice (lower left). Hematoxylin and eosin staining demonstrated robust bone and hematopoietic marrow regeneration in BM-MSC transplant mice (right). See Fang et al. beginning on page 1021.

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